Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION

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WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION Article in International Journal of Research – GRANTHAALAYAH · March 2020 DOI: 10.5281/zenodo.3724003 CITATIONS 8 1 author: jean-Claude Perez 93 PUBLICATIONS 390 CITATIONS SEE PROFILE Some of the authors of this publication are also working on these related projects: The Master Code of Biology View project The Master Code of Biology View project READS 22,018
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[PEREZ., Vol.8 (Iss.2): February 2020] ISSN- 2350-0530(O), ISSN- 2394-3629(P) Index Copernicus Value (ICV 2018): 86.20 DOI: 10.5281/zenodo.3724003

WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION

Jean-Claude PEREZ

Phd Maths & Computer Science Bordeaux University, RETIRED Interdisciplinary Researcher (IBM Emeritus, IBM European Research Center on Artificial Intelligence)

Abstract

The main result of this updated release is the formal proof that 2019-nCoV coronavirus is partially a SYNTHETIC genome. We proof the CONCENTRATION in a small région of wuhan New genome (300bp) of 3 different régions from HIV1 ENVELOPPE gene and 3 others from HIV2 and SIV (ENV and POL RT). All this is remarkable and bears the mark of a desire for organization of a human nature: LOGIC, SYMETRIES.

In this article, we demonstrate also that there is a kind of global human hosts adaptation strategy of SARS viruses as well as a strategy of global evolution of the genomes of the different strains of SARS which have emerged, mainly in China, between years 2003 first SARS genomes and the last 2019 COVID-19 Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome.

This global strategy, this temporal link, is materialized in our demonstration by highlighting stationary numerical waves controlling the entire sequence of their genomes.
Curiously, these digital waves characterizing the 9 SARS genomes studied here are characteristic whole numbers: the “Fibonacci numbers”, omnipresent in the forms of Nature, and which our research for several decades has shown strong links with the proportions of nucleotides in DNA. Here we demonstrate that the complexity and fractal multiplicity of these Fibonacci numerical waves increases over the years of the emergence of new SARS strains.

We suggest that this increase in the overall organization of the SARS genomes over the years reflects a better adaptation of SARS genomes to the human host.
The question of a link with pathogenicity remains open.
However, we believe that this overall strategy for the evolution of the SARS genomes ensures greater unity, consistency and integrity of the genome.

Finally, we ask ourselves the question of a possible artificial origin of this genome, in particular because of the presence of fragments of HIV1, HIV2 and SIV retroviruses.

Cite This Article: Jean-Claude PEREZ. (2020). “WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION.” International Journal of Research – Granthaalayah, 8(2), 285-324. https://doi.org/10.5281/zenodo.3724003.

1. Introduction

“Where there is matter, there is geometry.” – Johannes Kepler

Since the SARS coronavirus emergence 18 years ago, a large number of severe acute respiratory syndrome related coronaviruses (SARSr-CoV) have been discovered in their natural host, bats. Some of those bat SARSr-CoVs have the potential to infect humans. In january 2020, Wuhan China megacity was the origin of a Novel SARS disease entitled by OMS « COVID-19 » [6]. This novel coronavirus (COVID-19) caused an epidemic of respiratory syndrome in humans, in Wuhan, China then in other World countries (Iran South Korea, Italia…). As show in the following figures, we analyse in this article 9 whole SARS genomes with the goal to discover a possible strategy of SARS GENOMES EVOLUTION from 2003 original viruses to the 2020 WUHAN virus.

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

Secondly, for about 30 years, we have been looking for possible global, even digital, structures that would organize DNA, genes, chromosomes, and even whole genomes [27, 28, 30, 50, 51].

however, it is only by deepening the notion of “fractal periodicity”, outlined in [7, 38], and we will highlight here that we have re-discovered the major role of Fibonacci fractal stationary waves at both scales of each whole individual chromosomes and whole genome. We then demonstrate a sort of “hierarchical classification” of the 24 chromosomes. In this hierarchy, the chromosome4 seems to play a major and privileged role.

By comparing chromosome, the 3 reference genomes of Neanderthal, and Sapiens HG38 of 2013, we demonstrate the evidence of « fractal periods » and « Resonance periods» characterizing each of the 24 human chromosomes [47]. As illustrated in Figure1 below, these resonances make it possible to differentiate the respective genomes of Neanderthal and Sapiens on the global scale of the chromosome (here chromosome 4). Here, a resonance of 34 nucleotides is common to both chromosomes 4 of Sapiens and Neanderthal, however, the respective forms of these resonance curves are radically different.

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

Methods
The 9 Analysed Genomes:


Computing Fractal Periods and Resonances Summary

The complete description of this method can be found in [47], Six Fractal Codes of Biological Life: perspectives in Exobiology, Cancers Basic Research and Artificial Intelligence Biomimetism Decisions Making. Preprints 2018, 2018090139 (doi: 10.20944/preprints201809.0139.v1). https://www.preprints.org/manuscript/201809.0139/v1 We introduce here a method of global analysis of the roughness or fractal texture of the DNA sequences at the chromosome scale. To do this, we generalize the method of numerical analysis of the “Master Code of Biology” [39-42, 44]. Thus, we restructure the sequence into different generic sequences based on “meta codons” no longer triplets of 3 nucleotides but values ranging from 17 to 377 nucleotides, i.e 360 simulations. This method of analysis will then reveal, in most cases, discrete waves or interferences, most often dissonances. However, sometimes there will emerge kinds of resonances where all scales of analysis appear to be in symbiosis. Function: The Genomics master code (-II-) is generalized to meta-codons that no longer have 3 nucleotides as a codon, but 4, 5, … 377 nucleotides. Then we analyze the textures by the undulatory code (-IV-). It then appears dissonances and resonances that will reveal periods of discrete waves, resonances, and standing waves. The Genomics Binary code analysis (-III-) confirms these periods using a complementary independent method. Inputs: Double strand DNA sequence Pi-mass grouped by meta-codons (each Pi-mass is = -1 times number of « G » bases in meta-codon double strand or also = -1 times number of « C+G » bases in single strand meta-codon. Outputs: Period and resonance standing wave computed by two complementary methods. Http://www.granthaalayah.com ©International Journal of Research – GRANTHAALAYAH [288]

Summary: We introduce here a method of global analysis of the roughness or fractal texture of the DNA sequences at the chromosome scale. To do this, we generalize the method of numerical analysis of the “Master Code” [47 -II- ]. Thus, we restructure the sequence into different generic sequences based on “meta codons”, no longer triplets of 3 nucleotides, but values ranging from 17 to 377 nucleotides, ie 360 simulations. This method of analysis will then reveal, in most cases, discrete waves or interferences, most often dissonances (based on Genomics Undulatory waves described here in [47 -II- ]. However, sometimes there will emerge kinds of resonances where all scales of analysis appear to be in symbiosis.

Process: The discrete interferences fields resulting from the analysis of an entire chromosome are therefore a three- dimensional space: Dim y (vertical) restructuring in meta codons of lengths 17 to 377 nucleotides (or in this Coronavirus article meta codons 1bp to 100bp) Dim x (horizontal) Leibnitz differentiations such that primary 1/2 secondary 1/3… 1/4 … 1 / n Dim z cumulated populations from the “Master code” operators. The + 1 / -1 derivatives will be of type increase, ie +1 if derivative increasing and will be of type decrease, ie -1 if derived decreasing. In this context we will explore these 3D spaces in 2 forms:

  • Horizontally [47 -IV-], meta codons dimension: curves for a given meta codon dimension, see in the example “resonances” below (see Figure 3 and Figure 4).
  • Vertically [47 -III-], spectral differentiation: discrete series d2-d1 is +1 if increase and -1 if decrease (see Figure 5). We represent in top the +1 and in low the -1, (see Figure 5).
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

These two independent methods lead in all the cases analyzed to the same period value: here, for example, the period “horizontal scan” is a resonance of 22bp (Figure 4) and the period “vertical scan” is a period of repeatability of 22bp also (Figure 5).

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

Figure 4: Evidence of a resonance of 22bp period in the whole HG38 human reference chromosome21.

(see Figure 4 and Figure 5), [47 -IV-].

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

Figure 5: Confirmation of a 22bp period in the whole HG38 human reference chromosome21 [47 -IV-].

A third complementary method is presented here: knowing the period determined and confirmed by the two previous methods, we segment the complete sequence of the chromosome by consecutive segments according to this period, for example here for the chromosome21, we will “cut” the entire sequence of the chromosome in successive sections of 22 bases, the length of the period discovered. Then we record for each segment the C + G populations on the one hand and T + A on the other hand. We then represent the cumulative distribution curve of these different CG and TA populations throughout the chromosome sequence.

We then represent the cumulative distribution curve of these different CG and TA populations throughout the chromosome sequence (Table2).

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

The Figure 6 shows a C+G top for 8 bases value within 22 bases segments distribution. segmented by 22 bases periods.

3. Results and Discussion

• SARS2003


SARS Coronavirus SZ16, Complete Genome

https://www.ncbi.nlm.nih.gov/nuccore/Ay304488

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

In this initial SARS2003 genome, we find only the Fibonacci stationary wave 5bp (Figure 7). All other fractal waves 8,13, 21 bp are absent.

• SARS2004


Bat SARS coronavirus Rm1, complete genome


https://www.ncbi.nlm.nih.gov/nuccore/DQ412043

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

In this second SARS2004 genome, we find only the Fibonacci stationary wave 5bp (Figure 11). All other fractal waves 8,13, 21 bp are absent.

• SARS2004b

SARS Coronavirus ZS-C, Complete Genome

https://www.ncbi.nlm.nih.gov/nuccore/AY395003

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

In this third SARS2004b genome, we find only the Fibonacci stationary wave 5bp (Figure 15). All other fractal waves 8,13, 21 bp are absent.
• SARS2012

Bat SARS-Like Coronavirus Isolate Rs4084, Complete Genome – Nucleotide – NCBI. Ky417144.1

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

In this fourth SARS2012 genome, we find only the Fibonacci stationary wave 5bp (Figure 19). All other fractal waves 8,13, 21 bp are absent.

• SARS2015

Bat SARS-Like Coronavirus Isolate Bat-SL-Covzxc21, Complete Genome


https://www.ncbi.nlm.nih.gov/nuccore/Mg772934

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

In this fifth SARS2015 genome, we find now three Fractal Fibonacci stationary wave 5bp, 8bp, and 13bp (Figures 21, 22, 23). Meanwhile the fourth other fractal wave 21 bp remain absent.

• SARS2017


Bat SARS-Like Coronavirus Isolate Bat-SL-Covzc45, Complete Genome

https://www.ncbi.nlm.nih.gov/nuccore/Mg772933

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

In this sixth SARS2017 genome, we find also three Fractal Fibonacci stationary wave 5bp, 8bp, and 13bp (Figures 26, 27, 28). Meanwhile the fourth other fractal wave 21 bp remain absent.

WUHANOLD (first genome sequenced 12 january 2020) Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome MN908947.1

https://www.ncbi.nlm.nih.gov/nuccore/MN908947.1

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

WUHAN2 (second improved sequenced genome 14 January 2020) Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome GenBank: MN908947.2

https://www.ncbi.nlm.nih.gov/nuccore/MN908947.3?report=fasta

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

WUHAN (23 January 2020) Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome GenBank: MN908947.3

https://www.ncbi.nlm.nih.gov/nuccore/MN908947.3

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

4. Conclusions and Recommendations

Table 3 below clearly demonstrates a kind of evolution of SARS genomes between 2003 and 2020. If it remains difficult to associate this evolution with an increase in pathogenicity for humans, data already published by us [44-46] rather would suggest a greater ADAPTABILITY of these genomes to the human host genome by the same coherence and united via standing waves of Fibonacci [37].

Table3: High level of correlation between the years of emergence of the SARS virus and the presence of Fibonacci fractal standing waves.

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

In figure 44 we have superimposed the standing waves of 21bp corresponding to the 3 published versions of the wuhan genome of 2020. There appears a very high sensitivity, which suggests the fact that this new genome is in full phase of evolution in its adaptation to the human host. the 3 figures 33, 37, 42 show this evolution better: WUHANOLD: 3.5 waves, WUHAN2: one and epsilon wave, WUHAN: 2 waves.

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

Figure 44: High level of sensitivity for 3 releases of Wuhan CoV-2019 genomes of almost identical lengths (30473, 29875 and 29903bp).

How Could Tomorrow 2019-Ncov Evolve?

In [2] and [5], authors show that there is no doubt that 2019-nCoV is a novel unknown sequence. In an unformal draft, Dr Lyons-weiler [4] even suggests that a region between the bases 21600- 22350 bp would be completely new. Considering that this region could be “foreign” to the family of coronaviruses we tried to test how its absence could have had an impact on the waves that we reveal here. We then construct a hypothetical genome which would no longer have this insertion between the bases 21600-22350 bp. It then appears (Figure 45), for the first time a Fibonacci wave of 34bp. This genome would therefore be structured by a fractal nesting of 5 Fibonacci waves, 5 8 13 21 and now 34bp. Curiously, we have only encountered such a level of organization in the entire human chromosome4 (figure 46). A new question: “Can there be some kind of affinity between the waves of a retrovirus and the human host genome in which this retrovirus could integrate?”

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

On A Possible “Harmonic Standing Wave Agreement” Between the Human Host Chromosome and The Coronavirus Retrovirus:

This last observation opens here an interesting theoretical track on 2 possible strategies of integration of retroviruses in eucharyotic chromosomes:

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

1 / symbiosis strategy by complementarity: example of HIV more frequently integrating chromosomes 20 16 17 22 19. These chromosomes have a poor HGO (Human Genome Optimum) ratio, it will be slightly improved by the integration of the virus.

Indeed, in [8, 46], we demonstrated why the permeability to the integration of retrovirus in each of our chromosomes is correlated with this classification HGO (HUMAN GENOME OPTIMUM) of this article http://www.imedpub.com/abstract/towards-a-universal-law-controlling-all-human- cancer-chromosome-loh-deletions-perspectives-in-prostate-and-breast-cancers-screening- 20846.html

For example, chromosomes 20. 16. 17. 22 19 are very permeable: this table shows that they are located at the bottom of this table of classification of HGOs of 24 human chromosomes.

Table 3: HGO human chromosomes classification.

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

https://juniperpublishers.com/ctoij/images/CTOIJ.MS.ID.555756.T001.png

We also see in figure 47 from Figure 4 (Wang 2007), that these chromosomes are very permeable to the HIV retrovirus (Dark green bands in the following image from [3].

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

Figure 47: from [3] Green regions are retoviruses integration region,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385939/figure/A006890F4/

2 / symbiosis strategy by wave agreement, resemblance: this could be the case of the coronavirus which would integrate by a kind of harmonic agreement to chromosomes 4 or 13, located at the beginning of the HGO table, which have like it Fibonacci waves . This would hardly affect the resulting HGO ratio, or even strengthen it: This is surely the case with RETROTRANSPOSONS.

Finally, we have recognized here 2 laws of symbiosis of nature: agreement because very DIFFERENT, and agreement because very SIMILAR.
Strategies that we find up to the affinities between humans …!!!

If the genome of the 2019-nCoV retrovirus has adopted this second strategy of integration into the human genome, this could explain the fact observed at the beginning of 2020: a moderately pathogenic virus but which spreads very quickly … Because its retrovirus would be judiciously adapted to its (supposed) host chromosome4 of the human genome?

On A Possible Origin Of 2019-Ncov Genome:

It is very likely that there was HUMAN INTERVENTION in this LYONS’s region [4] of wuhan genome: Analysis of this region in all coronaviruses shows a 100% jump in homology for the Wuhan genomes and 70 to 80% for the closest SARS. Although there is already a trace of ENV HIV1 in the genome that we have referenced here SARS2003.

While there is NO TRACE of HIV1 ENV in the region (Lyons-weiler 20020) in all other SARS Coronavirus genomes, Indeed, we find on a mini region (243-86bp = ~ 160bp) 3 partial regions of ENV HIV1 which are all 3 “DIFFERENT” and from 3 different HIV1 strains:

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

in ENV HIV1 Here, these 3 regions, while hyper compressed in Lyons wuhan (<200bp), they are more widely spaced in hiv1 env (394 <==> 1228), ie> 830bp.??? HOW TO EXPLAIN THIS CONCENTRATION OF 3 SEQUENCES ENV HIV1???? IF NOT BY HUMAN ACTION?!!!!

Then, in a second time, we discovered 3 other regions from HIV2 and SIV… See details and Blast proves here:

Location of the 300 first bp in [4] from wuhan COVID-19 reference genome (starting from bp 21672).

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

To Conclude:

Figure 48: Double level of correlation between the years of emergence of the SARS virus, the presence of standing Fibonacci fractal waves, and the Fractal number of nested and embedded Fibonacci layers.

One track that will need to be deepened is that of integrating the SARS coronavirus genome into human chromosomes [9, 57].

Indeed, if we show that each of the 24 human chromosomes is characterized by one or more specific standing waves, some of our chromosomes (chromosomes 4 and 13 for example) have standing waves which are Fibonacci numbers [7]. There could then be a kind of harmonic agreement between the genome of the SARS virus and its human host chromosome, both of which have standing Fibonacci waves, which will facilitate and strengthen the integration and persistence of these viruses in humans.

Finally, That is a formal proof of an evolution increasing global structure of SARS whole genomes, probably linked with genome integrity and coherence and, human génome adaptation [8, 38] , perhaps pathogenicity.

Evidence of A Kind of “Intelligent Will” …

Please, now, see figures 49 then 50.Both figures proves evidence that the 6 HIV/SIV inserts are not the result of natural evolution and mutations.

Particularly,

  • Firstly, the 6 inserts are highly contiguous: 169bp within 275bp regions.
  • Secondly, HIV/SIV inserted strains are very homogeneous: Russia, Cote d’ivoire, Netherlands, Malawi origins.
  • Thirdly, the functions of inserts are also various: 2 from POL/RT, 4 from ENVELOPPE functional genes.
    Not reported in this article, wz found also within the COVID-19 genome 3 others HIV/SIV regions: one from ENVELOPPE, one from RT, and one from INTEGRASE.
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

All this is remarkable and bears the mark of a desire for organization of a human nature: LOGIC, SYMETRIES!!!!

This conclusion is summarized by Figure 49 below.

Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado
Figure 49
Formal Proof: WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION, Save Colorado

Ethical Considerations:

The 2 main results of this publication confront us with a paradox, in fact:

On the one hand, we have just demonstrated that this covid-19 genome contains an insertion of 6 strategic regions of HIV / SIV concentrated in a mini space representing less than 1% of the length of the genome. One can think that such a “disturbance” can only have affected the global order of the DNA of this genome.

On the other hand, we have also just shown that since the first SARS of 2003, the global order of successive genomes was only increasing, highlighted here by stationary digital waves calibrated on increasing Fibonacci numbers. In particular, covid-19 is structured over a long distance by a 21bp amplitude wave. However, the deletion in this genome of the small region including the 6 HIV / SIV inserts, will further gain in organization, causing waves of 34 bp to emerge (the number of Fibonacci following 21 bp).

We must conclude this remarkable fact:

To adapt to the disorder of its DNA resulting from the insertion of the 6 HIV / SIVs, the covid-19 genome has most certainly increased its level of global organization by adaptation mutations.And we will now have to fear that this genome will continue to mutate in order to optimize its overall level of organization …

Acknowledgements

We especially thank Dr. Robert Friedman M.D. practiced nutritional and preventive medicine in Santa Fe, New Mexico, woldwide expert on Golden ratio Life applications (https://tinyurl.com/y9dxaauv). We also thank the mathematician Pr. Diego Lucio Rapoport (Buenos aires), Marco F. Paya Torres (M.D Alicante), the french biologist Pr. François Gros (Pasteur institute,co-discoverer of RNA messenger with James Watson and Walter Gilbert ), Professor Sergey V. Petoukhov (Dr. Phys.-Math. Sci, Grand Ph.D., Full Professor, Laureate of the State prize of the USSR), Volkmar Weiss (Dr. rer. nat. habil. Dr. phil. Habil. Leipzig, Germany), and Pr. Luc Montagnier, medicine Nobel prizewinner for their interest in my research of biomathematical laws of genomes. I especially thank Professor Luc Montagnier for his advice and suggestions that led to this article.

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[PEREZ., Vol.8 (Iss.2): February 2020] ISSN- 2350-0530(O), ISSN- 2394-3629(P) Index Copernicus Value (ICV 2018): 86.20 DOI: 10.5281/zenodo.3724003

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